Lipopolysaccharide increases bitter taste sensitivity via epigenetic changes in Tas2r gene clusters.

ABSTRACT: T2R bitter receptors, encoded by Tas2r genes, are not only critical for bitter taste signal transduction but also important for defense against bacteria and parasites. However, little is known about whether and how Tas2r gene expression are regulated. Here, we show that in an inflammation model mimicking bacterial infection using lipopolysaccharide, the expression of many Tas2rs was significantly upregulated and mice displayed markedly increased neural and behavioral responses to bitter compounds. Using single-cell assays for transposase-accessible chromatin with sequencing (scATAC-seq), we found that the chromatin accessibility of Tas2rs was highly celltype specific and lipopolysaccharide increased the accessibility of many Tas2rs. scATAC-seq also reveal

SUBMITTER: Lin C 

PROVIDER: S-EPMC10239704 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature