D-Asparagine is an Ideal Endogenous Molecule for Measuring the Glomerular Filtration Rate.

ABSTRACT:

Introduction

An ideal endogenous molecule for measuring glomerular filtration rate (GFR) is still unknown. However, a rare enantiomer of serine, d-serine, is useful in GFR measurement. This study explored the potential of other d-amino acids for kidney function assessment.

Methods

This was a cross-sectional observational study of 207 living kidney transplant donors and recipients, for whom GFR was measured using clearance of inulin (C-in). Associations between levels of d-amino acids and GFR were analyzed using multivariate factor analysis. Fractional excretion (FE), a ratio of the clearance of a substance to C-in as a standard molecule, was calculated to monitor the excretion ratio after glomerular filtration. Dissociation from an ideal FE of 100% was assessed as a bias. Pr

SUBMITTER: Taniguchi A 

PROVIDER: S-EPMC10239771 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature