Heterogeneity of Target Antigens in Sarcoidosis-Associated Membranous Nephropathy.

ABSTRACT:

Introduction

Membranous nephropathy (MN) is the most common glomerular disease associated with sarcoidosis. The target antigen M-type phospholipase A2 receptor 1 (PLA2R) has been identified in a subset of sarcoidosis-associated MN. The target antigen is not known in the remaining sarcoidosis-associated MN.

Methods

Data of patients with history of sarcoidosis and biopsy-proven MN were retrieved and analyzed. Mass spectrometry (MS/MS) was performed on all kidney biopsies of sarcoidosis-associated MN to detect the target antigens. Immunohistochemistry (IHC) studies were performed to confirm and localize the target antigens along the glomerular basement membrane (GBM).

Results

Eighteen patients with history of sarcoidosis and biopsy-proven MN were identified, of whom 3 we

SUBMITTER: Zubidat D 

PROVIDER: S-EPMC10239775 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature