Genetically predicted vitamin C levels significantly affect patient survival and immunotypes in multiple cancer types.

ABSTRACT:

Background

Recent observational studies and meta-analyses have shown that vitamin C reduces cancer incidence and mortality, but the underlying mechanisms remain unclear. We conducted a comprehensive pan-cancer analysis and biological validation in clinical samples and animal tumor xenografts to understand its prognostic value and association with immune characteristics in various cancers.

Methods

We used the Cancer Genome Atlas gene expression data involving 5769 patients and 20 cancer types. Vitamin C index (VCI) was calculated using the expression of 11 genes known to genetically predict vitamin C levels, which were classified into high and low subgroups. The correlation between VCI and patient overall survival (OS), tumor mutational burden (TMB), microsatellite instabilit

SUBMITTER: Yuan J 

PROVIDER: S-EPMC10239825 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature