Identification of necroptosis-related genes in Parkinson's disease by integrated bioinformatics analysis and experimental validation.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most common neurodegeneration disease worldwide. Necroptosis, which is a new form of programmed cell death with high relationship with inflammation, plays a vital role in the progression of PD. However, the key necroptosis related genes in PD are not fully elucidated.

Purpose

Identification of key necroptosis-related genes in PD.

Method

The PD associated datasets and necroptosis related genes were downloaded from the GEO Database and GeneCards platform, respectively. The DEGs associated with necroptosis in PD were obtained by gap analysis, and followed by cluster analysis, enrichment analysis and WGCNA analysis. Moreover, the key necroptosis related genes were generated by PPI network analysis and their relationship by

SUBMITTER: Lei C 

PROVIDER: S-EPMC10239842 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature