Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.

ABSTRACT:

Introduction

Recent reports indicate that mitochondrial quality decreases during non-alcoholic fatty liver disease (NAFLD) progression, and targeting the mitochondria may be a possible treatment for NAFLD. Exercise can effectively slow NAFLD progression or treat NAFLD. However, the effect of exercise on mitochondrial quality in NAFLD has not yet been established.

Methods

In the present study, we fed zebrafish a high-fat diet to model NAFLD, and subjected the zebrafish to swimming exercise.

Results

After 12 weeks, swimming exercise significantly reduced high-fat diet-induced liver injury, and reduced inflammation and fibrosis markers. Swimming exercise improved mitochondrial morphology and dynamics, inducing upregulation of optic atrophy 1(OPA1), dynamin related protei

SUBMITTER: Zou YY 

PROVIDER: S-EPMC10239848 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature