CD44 targeted delivery of oncolytic Newcastle disease virus encapsulated in thiolated chitosan for sustained release in cervical cancer: a targeted immunotherapy approach.

ABSTRACT:

Introduction

Cervical cancer accounts for one of most common cancers among women of reproductive age. Oncolytic virotherapy has emerged as a promising immunotherapy modality but it comes with several drawbacks that include rapid clearance of virus from body due to immune-neutralization of virus in host. To overcome this, we encapsulated oncolytic Newcastle disease virus (NDV) in polymeric thiolated chitosan nanoparticles. For active targeting of virus loaded nanoformulation against CD44 (cluster of differentiation 44) receptors which are overly expressed on cancer cells, these nanoparticles were surface functionalized with hyaluronic acid (HA).

Methods

Using half dose of NDV (TCID₅₀ (50% tissue culture infective dose) single dose 3 × 10⁵), virus loaded

SUBMITTER: Kousar K 

PROVIDER: S-EPMC10239954 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature