Risk factors associated with amyotrophic lateral sclerosis based on the observational study: a systematic review and meta-analysis.

ABSTRACT:

Objective

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the upper and lower motor neurons. Though the pathogenesis of ALS is still unclear, exploring the associations between risk factors and ALS can provide reliable evidence to find the pathogenesis. This meta-analysis aims to synthesize all related risk factors of ALS to understand this disease comprehensively.

Methods

We searched the following databases: PubMed, EMBASE, Cochrane library, Web of Science, and Scopus. Moreover, observational studies, including cohort studies, and case-control studies, were included in this meta-analysis.

Results

A total of 36 eligible observational studies were included, and 10 of them were cohort studies and the rest were case-control studies. We

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10239956 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature