Identifying reproducible resting state networks and functional connectivity alterations following chronic restraint stress in anaesthetized rats.

ABSTRACT:

Background

Resting-state functional MRI (rs-fMRI) in rodent models have the potential to bridge invasive experiments and observational human studies, increasing our understanding of functional alterations in the brains of patients with depression. A major limitation in current rodent rs-fMRI studies is that there has been no consensus on healthy baseline resting-state networks (RSNs) that are reproducible in rodents. Therefore, the present study aimed to construct reproducible RSNs in a large dataset of healthy rats and then evaluate functional connectivity changes within and between these RSNs following a chronic restraint stress (CRS) model within the same animals.

Methods

A combined MRI dataset of 109 Sprague Dawley rats at baseline and after two weeks of CRS, collected d

SUBMITTER: Dai T 

PROVIDER: S-EPMC10239969 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature