Insights into the epigenetics of chronic rhinosinusitis with and without nasal polyps: a systematic review

ABSTRACT:

Background

Epigenetics facilitates insights on the impact of host environment on the genesis of chronic rhinosinusitis (CRS) through modulations of host gene expression and activity. Epigenetic mechanisms such as DNA methylation cause reversible but heritable changes in gene expression over generations of progeny, without altering the DNA base-pair sequences. These studies offer a critical understanding of the environment-induced changes that result in host predisposition to disease and may help in developing novel biomarkers and therapeutics. The goal of this systematic review is to summarize the current evidence on epigenetics of CRS with a focus on chronic rhinosinusitis with nasal polyps (CRSwNP) and highlight gaps that merit further research.

Methods

A systematic rev

SUBMITTER: Brar T 

PROVIDER: S-EPMC10240395 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature