Ontology highlight
ABSTRACT: Significance
HAND2 and MYCN compete with nucleosomes to regulate global gene transcription and to drive a malignant neuroblastoma phenotype.
SUBMITTER: Xu M
PROVIDER: S-EPMC10240397 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Xu Man M Sun Ming M Zhang Xiyuan X Nguyen Rosa R Lei Haiyan H Shern Jack F JF Thiele Carol J CJ Liu Zhihui Z
Cancer research 20230301 5
Noradrenergic neuroblastoma is characterized by a core transcriptional regulatory circuitry (CRC) comprised of transcription factors (TF) such as PHOX2B, HAND2, and GATA3, which form a network with MYCN. At normal physiologic levels, MYCN mainly binds to promoters but when aberrantly upregulated as in neuroblastoma, MYCN also binds to enhancers. Here, we investigated how MYCN invades enhancers and whether CRC TFs play a role in this process. HAND2 was found to regulate chromatin accessibility an ...[more]