Crosstalk of protein clearance, inflammasome, and Ca²⁺ channels in retinal pigment epithelium derived from age-related macular degeneration patients.

ABSTRACT: Degeneration and/or dysfunction of retinal pigment epithelium (RPE) is generally detected as the formation of intracellular and extracellular protein aggregates, called lipofuscin and drusen, respectively, in patients with age-related macular degeneration (AMD), the leading cause of blindness in the elderly population. These clinical hallmarks are linked to dysfunctional protein homeostasis and inflammation and furthermore, are both regulated by changes in intracellular Ca²⁺ concentration. While many other cellular mechanisms have been considered in the investigations of AMD-RPE, there has been relatively little work on understanding the interactions of protein clearance, inflammation, and Ca²⁺ dynamics in disease pathogenesis. Here we established induced pluripotent

SUBMITTER: Karema-Jokinen V 

PROVIDER: S-EPMC10240424 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature