The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap.

ABSTRACT: Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a risk factor for Alzheimer's disease. While the role of chronic peripheral inflammation has been well characterized in the context of dementia and other age-related conditions, less is known about the neurologic contribution of acute inflammatory insults that take place outside the central nervous system. Herein, we define acute inflammatory insults as an immune challenge in the form of pathogen exposure (e.g., viral infection) or tissue damage (e.g., surgery) that causes a large, yet time-limited, inflammatory response. We provide an overview of the clinical and translational research that has examined the connection between acute infla

SUBMITTER: Walker KA 

PROVIDER: S-EPMC10240487 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature