Odor-evoked layer-specific fMRI activities in the awake mouse olfactory bulb.

ABSTRACT: Awake rodent fMRI is increasingly common over the use of anesthesia since it permits behavioral paradigms and does not confound normal brain function or neurovascular coupling. It is well established that adequate acclimation to the loud fMRI environment and head fixation reduces stress in the rodents and allows for whole brain imaging with little contamination from motion. However, it is unknown whether high-resolution fMRI with increased susceptibility to motion and lower sensitivity can measure small, but spatially discrete, activations in awake mice. To examine this, we used contrast-enhanced cerebral blood volume-weighted (CBVw) fMRI in the mouse olfactory bulb for its enhanced sensitivity and neural specificity. We determined that activation patterns in the glomerular layer to four d

SUBMITTER: Poplawsky AJ 

PROVIDER: S-EPMC10240534 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature