Aspartoacylase suppresses prostate cancer progression by blocking LYN activation.

ABSTRACT:

Background

Globally, despite prostate cancer (PCa) representing second most prevalent malignancy in male, the precise molecular mechanisms implicated in its pathogenesis remain unclear. Consequently, elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies, ultimately advancing the management of PCa.

Methods

A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan University. The advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in PCa. The expression of aspartoacylase (ASPA) in PCa was thoroughly evaluated using quantitative real-time PCR and Western bl

SUBMITTER: Weng H 

PROVIDER: S-EPMC10240701 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature