Disulfiram with Cu²⁺ alleviates dextran sulfate sodium-induced ulcerative colitis in mice.

ABSTRACT: Background: Disulfiram (DSF), a Food and Drug Administration (FDA)-approved drug for chronic alcohol addiction, has anti-inflammatory effects that help prevent various cancers, and Cu²⁺ can enhance the effects of DSF. Inflammatory bowel diseases (IBD) are characterized by chronic or recurrent relapsing gastrointestinal inflammation. Many drugs targeting the immune responses of IBD have been developed, but their application has many problems, including side effects and high costs. Therefore, there is an urgent need for new drugs. In this study, we investigated the preventive effects of DSF+Cu²⁺ on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. Methods: The anti-inflammatory effects were investigated using the DSS-induced colitis mou

SUBMITTER: Zhou W 

PROVIDER: S-EPMC10240830 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature