An inducible expression system for the manipulation of autophagic flux in vivo.

ABSTRACT: Much of our understanding of the intracellular regulation of macroautophagy/autophagy comes from in vitro studies. However, there remains a paucity of knowledge about how this process is regulated within different tissues during development, aging and disease in vivo. Because upregulation of autophagy is considered a promising therapeutic strategy for the treatment of diverse disorders, it is vital that we understand how this pathway functions in different tissues and this is best done by in vivo analysis. Similarly, to understand the role of autophagy in the pathogenesis of disease, it is important to study this process in the whole animal to investigate how tissue-specific changes in flux and cell-autonomous versus non-cell-autonomous effects alter disease pro

SUBMITTER: Schlotawa L 

PROVIDER: S-EPMC10240996 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature