Radioimmunoscintigraphy and Pretreatment Dosimetry of ¹³¹I-Omburtamab for Planning Treatment of Leptomeningeal Disease.

ABSTRACT: Radiolabeled antibody treatment with ¹³¹I-omburtamab, administered intraventricularly into the cerebrospinal fluid (CSF) space, can deliver therapeutic absorbed doses to sites of leptomeningeal disease. Assessment of distribution and radiation dosimetry is a key element in optimizing such treatments. Using a theranostic approach, we performed pretreatment ¹³¹I-omburtamab imaging and dosimetric analysis in patients before therapy. Methods: Whole-body planar images were acquired 3 ± 1, 23 ± 2, and 47 ± 2 h after intracranioventricular administration of 75 ± 5 MBq of ¹³¹I-omburtamab via an Ommaya reservoir. Multiple blood samples were also obtained for kinetic analysis. Separate regions of interest (ROIs) were manually drawn to include the lateral ventr

SUBMITTER: Pandit-Taskar N 

PROVIDER: S-EPMC10241015 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature