Association between free thyroxine levels and clinical phenotype in first-episode psychosis: a prospective observational study.

ABSTRACT:

Aim

To determine whether thyroid hormone levels are associated with a specific clinical phenotype in patients with first-episode psychosis (FEP).

Methods

Ninety-eight inpatients experiencing FEP and with less than 6 weeks of antipsychotic treatment were included in the study and were followed up for one year. Baseline psychiatric evaluation included assessment of prodromal symptoms, positive and negative symptoms, depressive symptoms, stressful life events and cycloid psychosis criteria. Thyroid function (thyroid-stimulating hormone (TSH) and free thyroxin (FT4)) was determined at admission. Partial correlation analysis was conducted to analyse the correlation between levels of TSH/FT4 and symptoms. Logistic regression was performed to explore the association between psychop

SUBMITTER: Gine-Serven E 

PROVIDER: S-EPMC10241168 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature