Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages.

ABSTRACT: Although inflammation is a vital defence response to infection, if left uncontrolled, it can lead to pathology. Macrophages are critical players both in driving the inflammatory response and in the subsequent events required for restoring tissue homeostasis. Extracellular vesicles (EVs) are membrane-enclosed structures released by cells that mediate intercellular communication and are present in all biological fluids, including blood. Herein, we show that extracellular vesicles from plasma (pEVs) play a relevant role in the control of inflammation by counteracting PAMP-induced macrophage activation. Indeed, pEV-treatment of macrophages simultaneously with or prior to PAMP exposure reduced the secretion of pro-inflammatory IL-6 and TNF-α and increased IL-10 response. This anti-inflammatory

SUBMITTER: Adamczyk AM 

PROVIDER: S-EPMC10241174 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature