No long-term effect of past Pneumocystis jirovecii pneumonia on pulmonary function in people with HIV.

ABSTRACT:

Objective

To assess the impact of past Pneumocystis jirovecii pneumonia (PJP) on the pulmonary diffusion capacity in people with HIV (PWH) with a history of advanced immunodeficiency.

Design

Prospective cross-sectional study.

Methods

Adult PWH with past PJP >1 year ago were included as the study group. The control group consisted of PWH with a nadir CD4 + lymphocyte count <200 cells/mm 3 , matched by age, sex, smoking status and time since HIV diagnosis. All PWH completed a pulmonary function test (PFT) consisting of pre-bronchodilation spirometry, body plethysmography and single-breath carbon monoxide transfer factor (TLCO) measurement. TLCO, diffusion impairment (defined as a TLCO Z -score <-1.645), total lung capacity (TLC) and forced expiratory volume in one secon

SUBMITTER: Oomen PGA 

PROVIDER: S-EPMC10241413 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature