Childhood obesity and hypertension in pregnancy: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

The causal relationship between childhood obesity and hypertension in pregnancy remains unclear. To examine the causal association between childhood obesity and hypertension in pregnancy, two-sample Mendelian randomization analysis was applied.

Methods

Single-nucleotide polymorphisms (SNPs) associated with childhood obesity were obtained from a published genome-wide association study (GWAS) of 13 848 European individuals. Summary-level data for hypertension in pregnancy were obtained from the FinnGen consortium (11534 cases and 162212 controls). Inverse-variance weighted analysis, weighted-median analysis, and Mendelian randomization-Egger regression were conducted in this Mendelian randomization analysis. Sensitivity analyses were conducted to confirm the accurac

SUBMITTER: Hu B 

PROVIDER: S-EPMC10241434 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature