A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity.

ABSTRACT: Different anatomical locations of the body skin show differences in their gene expression patterns depending on different origins, and the inherent heterogeneous information can be maintained in adults. However, highly resolvable cellular specialization is less well characterized in different anatomical regions of the skin. Pig is regarded as an excellent model animal for human skin research in view of its similar physiology to human. In this study, single-cell RNA sequencing was performed on pig skin tissues from six different anatomical regions of Chenghua (CH) pigs, with a superior skin thickness trait, and the back site of large white (LW) pigs. We obtained 233,715 cells, representing seven cell types, among which we primarily characterized the heterogeneity of the top three cell types

SUBMITTER: Zou Q 

PROVIDER: S-EPMC10241519 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature