Changing nationwide trends away from overtreatment among patients undergoing radical prostatectomy over the past 25 years.

ABSTRACT:

Purpose

The objective of the current study was to assess whether and how preoperative risk group distribution and pathological outcomes have changed in men treated with radical prostatectomy (RP) over the past 25 years.

Methods

11,071 patients from a large contemporary registry-based nationwide cohort with RP as primary treatment between 1995 and 2019 were included. Preoperative risk stratification, postoperative outcomes, and 10 years other-cause mortality (OCM) were analyzed.

Results

After 2005, the proportion of low-risk prostate cancer (PCa) decreased from 39.6% to 25.5% in 2010 and decreased further to 15.5% in 2015, and 9.4% in 2019 (p < 0.001). The proportion of high-risk cases increased from 13.1% in 2005 to 23.1% in 2010 and 36.7% in 2015, and 40.4% in 2019 (

SUBMITTER: Meissner VH 

PROVIDER: S-EPMC10241676 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature