The Landscape of Currently Enrolling Maintenance Trials in Multiple Myeloma.
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ABSTRACT:
SUBMITTER: Tariq SM
PROVIDER: S-EPMC10241733 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Publications
The Landscape of Currently Enrolling Maintenance Trials in Multiple Myeloma.
Tariq Syed Maaz SM Abdallah Al-Ola AO Goodman Aaron A Sborov Douglas D Mohyuddin Ghulam Rehman GR Britt Alec A
Clinical hematology international 20230503 2-3
Maintenance therapies in multiple myeloma improve survival after induction treatment. This study characterizes the strategies for maintenance therapy being employed in currently enrolling clinical trials for patients with multiple myeloma and highlights how high-risk myeloma patients may be assigned to maintenance strategies incongruent with current US guidelines. ...[more]
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Project description:Transplant-eligible patients with multiple myeloma (MM) now have extended survival after diagnosis owing to effective modern treatment strategies that include new agents in induction therapy, autologous stem cell transplant (ASCT), consolidation therapy and posttransplant maintenance therapy. Standard of care for newly diagnosed, fit patients includes ASCT and, often nowadays, posttransplant maintenance. Several large studies have shown the efficacy of maintenance with thalidomide, lenalidomide and bortezomib in the treatment scheme of MM with regards to prolonging progression-free survival and, to a lesser degree, overall survival. Herein we discuss the data currently available to support the use of maintenance therapy in patients after ASCT as well as the newer available agents that may be a part of its changing landscape in the years to come.
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