Understanding the impact of disease and vaccine mechanisms on the importance of optimal vaccine allocation.

ABSTRACT: Vaccination is an important epidemic intervention strategy. However, it is generally unclear how the outcomes of different vaccine strategies change depending on population characteristics, vaccine mechanisms and allocation objective. In this paper we develop a conceptual mathematical model to simulate strategies for pre-epidemic vaccination. We extend the SEIR model to incorporate a range of vaccine mechanisms and disease characteristics. We then compare the outcomes of optimal and suboptimal vaccination strategies for three public health objectives (total infections, total symptomatic infections and total deaths) using numerical optimisation. Our comparison shows that the difference in outcomes between vaccinating optimally and suboptimally depends on vaccine mechanisms, disease characte

SUBMITTER: Abell IR 

PROVIDER: S-EPMC10241858 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature