Immunological and prognostic significance of tumour necrosis in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC.

Methods

Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined.

Results

Higher tumour necrosis percentage associated with shorter colorectal cancer-specific survival independent of tumour grad

SUBMITTER: Kastinen M 

PROVIDER: S-EPMC10241859 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature