Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer.

ABSTRACT:

Background

In EGFR-mutant and MET-amplified lung cancer resistant to EGFR inhibitors, double blockade of EGFR and MET is considered as a reasonable strategy despite increasing toxicity. This study evaluated the single MET inhibition in these specific tumours.

Methods

We investigated the efficacy of a single MET inhibitor in EGFR-mutant, MET-amplified lung cancer cells (HCC827GR) and the matched clinical cases and patient-derived cells. Acquired resistance mechanisms to single MET inhibitor were further explored.

Results

Single MET inhibitor sufficiently inhibited the EGFR downstream signalling and proliferation in the HCC827GR cells. The MET-inhibitor-sensitive clones had similar EGFR mutation allele frequency as the MET-inhibitor-resistant clones. The patients with E

SUBMITTER: Choi YR 

PROVIDER: S-EPMC10241937 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature