Multiple ParA/MinD ATPases coordinate the positioning of disparate cargos in a bacterial cell.

ABSTRACT: In eukaryotes, linear motor proteins govern intracellular transport and organization. In bacteria, where linear motors involved in spatial regulation are absent, the ParA/MinD family of ATPases organize an array of genetic- and protein-based cellular cargos. The positioning of these cargos has been independently investigated to varying degrees in several bacterial species. However, it remains unclear how multiple ParA/MinD ATPases can coordinate the positioning of diverse cargos in the same cell. Here, we find that over a third of sequenced bacterial genomes encode multiple ParA/MinD ATPases. We identify an organism (Halothiobacillus neapolitanus) with seven ParA/MinD ATPases, demonstrate that five of these are each dedicated to the spatial regulation of a single cellular cargo, and define

SUBMITTER: Pulianmackal LT 

PROVIDER: S-EPMC10241942 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature