Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood to develop new treatment strategies. We aimed to unravel the evolution of ICC and identify ICC-specific metabolic characteristics to investigate the metabolic pathway associated with ICC development using multiregional sampling to encompass the intra- and inter-tumoral heterogeneity.

Methods

We performed the genomic, transcriptomic, proteomic and metabolomic analysis of 39-77 ICC tumour samples and eleven normal samples. Further, we analysed their cell proliferation and viability.

Results

We demo

SUBMITTER: Kitagawa A 

PROVIDER: S-EPMC10241955 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature