Pleiotropic effects of a high confidence Autism Spectrum Disorder gene, arid1b, on zebrafish sleep.

ABSTRACT: Sleep fulfills critical functions in neurodevelopment, such as promoting synaptic plasticity, neuronal wiring, and brain connectivity which are critical phenomena in Autism Spectrum Disorder (ASD) pathophysiology. Sleep disturbance, specifically insomnia, accompanies ASD and is associated with more severe core symptoms (e.g., social impairment). It is possible that focusing on identifying effective ways to treat sleep problems can help alleviate other ASD-related symptoms. A body of evidence indicates shared mechanisms and neurobiological substrates between sleep and ASD and investigation of these may inform therapeutic effects of improving sleep at both behavioral and molecular levels. In this study, we tested if sleep and social behavior were different in a zebrafish model with the ar

SUBMITTER: Doldur-Balli F 

PROVIDER: S-EPMC10241967 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature