Association between breast cancer and thyroid cancer risk: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Breast and thyroid cancer are increasingly prevalent, but it remains unclear whether the observed associations are due to heightened medical surveillance or intrinsic etiological factors. Observational studies are vulnerable to residual confounding, reverse causality, and bias, which can compromise causal inference. In this study, we employed a two-sample Mendelian randomization (MR) analysis to establish a causal link between breast cancer and heightened thyroid cancer risk.

Methods

We obtained the single nucleotide polymorphisms (SNPs) associated with breast cancer from a genome-wide association study (GWAS) conducted by the Breast Cancer Association Consortium (BCAC). The FinnGen consortium's latest and largest accessible GWAS thyroid cancer data at the summary

SUBMITTER: Tan H 

PROVIDER: S-EPMC10242035 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature