Transcriptome data analysis of primary cardiomyopathies reveals perturbations in arachidonic acid metabolism.

ABSTRACT:

Introduction

Cardiomyopathies are complex heart diseases with significant prevalence around the world. Among these, primary forms are the major contributors to heart failure and sudden cardiac death. As a high-energy demanding engine, the heart utilizes fatty acids, glucose, amino acid, lactate and ketone bodies for energy to meet its requirement. However, continuous myocardial stress and cardiomyopathies drive towards metabolic impairment that advances heart failure (HF) pathogenesis. So far, metabolic profile correlation across different cardiomyopathies remains poorly understood.

Methods

In this study, we systematically explore metabolic differences amongst primary cardiomyopathies. By assessing the metabolic gene expression of all primary cardiomyopathies, we highlight t

SUBMITTER: Chauhan PK 

PROVIDER: S-EPMC10242083 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature