Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan.

ABSTRACT:

Purpose

Phthalates are ubiquitous endocrine disruptors that can affect pubertal development in children. The association of fetal and childhood levels of phthalates with pubertal development were explored.

Methods

We conduct a population-based birth cohort study to investigate the association between prenatal and childhood exposure to phthalates and pubertal development. Initially, a total of 445 children were recruited from 2000 to 2001, of which 90 children were followed for 15 years which measurements of urine and development assessed at 2, 5, 8, 11, and 14 years. We defined higher Tanner stage as the 14-year-old Tanner stage ≥ 4 and 5 for boys and girls, respectively. A logistic regression analysis was conducted to estimate the crude and adjusted odds ratio of a higher T

SUBMITTER: Su PH 

PROVIDER: S-EPMC10242106 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature