Exhaustion of CD8⁺ central memory responder T cell differentiation provokes non-melanoma skin cancer in elderly kidney transplant recipients.

ABSTRACT:

Introduction

Immunosuppressive therapy prevents graft rejection but increases the risk of non-melanoma skin cancer (NMSC), especially in elderly kidney transplant recipients (KTR).

Methods

In this study, we separately investigated the differentiation of CD8⁺ regulatory T cells (Tregs) and responder T cells (Tresps) between healthy KTR without NMSC, KTR developing de-novo NMSC within two years after the enrolment, and KTR with NMSC at the time of enrolment. Antigen-unexperienced CCR7⁺CD45RA⁺CD31⁺ recent thymic emigrant (RTE) cells differentiate via CD45RA^-CD31⁺ memory (CD31⁺ memory) cells, via resting mature naïve (MN) cells or via direct proliferation into CD45RA^-

SUBMITTER: Leonhard J 

PROVIDER: S-EPMC10242110 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature