YuNu-Jian attenuates diabetes-induced cardiomyopathy: integrating network pharmacology and experimental validation.

ABSTRACT:

Introduction

Diabetic cardiomyopathy (DCM) is one of the most prevalent complications of diabetes with complex pathogenesis. YuNü-Jian (YNJ) is a traditional Chinese medicinal formula widely used for diabetes with hypoglycemic and cardioprotective effects. This study aims to investigate the actions and mechanisms of YNJ against DCM which has never been reported.

Methods

Network pharmacology approach was used to predict the potential pathways and targets of YNJ on DCM. Molecular docking between hub targets and active components of YNJ was performed and visualized by AutoDock Vina and PyMOL. Then type 2 diabetic model was employed and intervened with YNJ for 10 weeks to further validate these critical targets.

Results

First, a total of 32 main ingredients of YNJ were id

SUBMITTER: Wang W 

PROVIDER: S-EPMC10242144 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature