Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice.

ABSTRACT:

Introduction

Gut-microbiota-brain axis is a potential treatment to decrease the risk of chronic traumatic encephalopathy following traumatic brain injury (TBI). Phosphoglycerate mutase 5 (PGAM5), a mitochondrial serine/threonine protein phosphatase, resides in mitochondrial membrane and regulates mitochondrial homeostasis and metabolism. Mitochondria mediates intestinal barrier and gut microbiome.

Objectives

This study investigated the association between PGAM5 and gut microbiota in mice with TBI.

Methods

The controlled cortical impact injury was established in mice with genetically-ablated Pgam5 (Pgam5^-/-) or wild type, and WT male mice were treated with fecal microbiota transplantation (FMT) from male Pgam5^-/- mice or Ak

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10242175 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature