Direct assessment of microcirculation in shock: a randomized-controlled multicenter study.

ABSTRACT:

Purpose

Shock is a life-threatening condition characterized by substantial alterations in the microcirculation. This study tests the hypothesis that considering sublingual microcirculatory perfusion variables in the therapeutic management reduces 30-day mortality in patients admitted to the intensive care unit (ICU) with shock.

Methods

This randomized, prospective clinical multicenter trial-recruited patients with an arterial lactate value above two mmol/L, requiring vasopressors despite adequate fluid resuscitation, regardless of the cause of shock. All patients received sequential sublingual measurements using a sidestream-dark field (SDF) video microscope at admission to the intensive care unit (± 4 h) and 24 (± 4) hours later that was performed blindly to the treatment t

SUBMITTER: Bruno RR 

PROVIDER: S-EPMC10242221 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature