Frailty trajectory predicts subsequent cognitive decline: A 26-year population-based longitudinal cohort study.

ABSTRACT: Frailty refers to a decline in the physiological functioning of one or more organ systems. It remained unclear whether variations in the trajectory of frailty over time were associated with subsequent cognitive change. The aim of the current study was to investigate the association between frailty trajectories and subsequent cognitive decline based on the Health and Retirement Study (HRS). A total of 15,454 participants were included. The frailty trajectory was assessed using the Paulson-Lichtenberg Frailty Index, while the cognitive function was evaluated using the Langa-Weir Classification. Results showed that severe frailty was significantly associated with the subsequent decline in cognitive function (β [95% CI] = -0.21 [-0.40, -0.03], p = 0.03). In the five identified fr

SUBMITTER: Li R 

PROVIDER: S-EPMC10242271 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature