Advances in immune checkpoint inhibitors therapy for small cell lung cancer.

ABSTRACT:

Background

As one of the most aggressive neuroendocrine tumors, small cell lung cancer (SCLC) has the most disappointing prognosis of all lung cancers. Although SCLC responds well to initial chemotherapy, the majority of patients experience disease recurrence within one year, and patient survival is poor. It is still necessary to explore the application of ICIs in SCLC since the beginning of the road to immunotherapy, which broke the 30-year treatment deadlock of SCLC.

Methods

We searched PubMed, Web of Science, and Embase with search terms such as "SCLC", "ES-SCLC", "ICIs", and "ICBs", and categorized and summarized the relevant literature obtained, and we compiled the latest progress about the application of ICIs in SCLC.

Results

We listed 14 clinical trials on ICIs

SUBMITTER: Li L 

PROVIDER: S-EPMC10242320 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature