Autophagy: A challengeable paradox in cancer treatment.

ABSTRACT:

Objective

Autophagy is an intracellular degradation pathway conserved in all eukaryotes from yeast to humans. This process plays a quality-control role by destroying harmful cellular components under normal conditions, maintaining cell survival, and establishing cellular adaptation under stressful conditions. Hence, there are various studies indicating dysfunctional autophagy as a factor involved in the development and progression of various human diseases, including cancer. In addition, the importance of autophagy in the development of cancer has been highlighted by paradoxical roles, as a cytoprotective and cytotoxic mechanism. Despite extensive research in the field of cancer, there are many questions and challenges about the roles and effects suggested for autophagy in cancer t

SUBMITTER: Ahmadi-Dehlaghi F 

PROVIDER: S-EPMC10242330 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature