Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.

ABSTRACT:

Backgorund

Colorectal cancer (CRC) is among the leading causes of cancer-related deaths among Hispanics living in the United States (USH). Understanding the most common carcinogenic molecular pathways that affect Hispanics with CRC is crucial to guide research efforts in developing new therapeutic modalities incorporating genomically diverse populations. Tumor profiling techniques help identify actionable alternatives to recommend treatment and improve survival in cancer patients.

Methods

We conducted a secondary data analysis to evaluate the mutational profile of 218 CRC tumors in Hispanics living in Puerto Rico (PRH) who underwent next-generation sequencing (NGS) testing from 2015 to 2020. We compared the prevalence of CRC tumor somatic mutations in PRHs with the mutationa

SUBMITTER: Montes-Rodriguez IM 

PROVIDER: S-EPMC10242354 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature