Rethinking the potential and necessity of drug delivery systems in neovascular age-related macular degeneration therapy.

ABSTRACT: Age-related macular degeneration (AMD) is the predominant threat to human vision and ultimately results in blindness. With the increase in the aging population, it has become a more crucial issue to human health. AMD is a multifactorial disease with the unique feature of uncontrollable angiogenesis during initiation and progression. Although increasing evidence indicates that AMD is largely hereditary, the predominant efficient treatment is antiangiogenesis, which mainly involves VEGF and HIF-α as therapeutic targets. The repeated administration of this treatment over the long term, generally through intravitreal injection, has called for the introduction of long-term drug delivery systems, which are expected to be achieved by biomaterials. However, the clinical results of the port deliver

SUBMITTER: Huang X 

PROVIDER: S-EPMC10242387 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature