Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring.

ABSTRACT: There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neur

SUBMITTER: Eisenkolb VM 

PROVIDER: S-EPMC10242451 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature