Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial.

ABSTRACT:

Importance

Due to the potential risks of long-term systemic estrogen therapy, many menopausal women are interested in nonhormonal treatments for vasomotor symptoms. Physiologic studies indicate that nitric oxide plays a key role in mediating hot flash-related vasodilation, suggesting that nonhormonal medications that induce nitrate tolerance in the vasculature may offer therapeutic benefit for vasomotor symptoms.

Objective

To determine whether uninterrupted administration of transdermal nitroglycerin (NTG) to induce nitrate cross-tolerance decreased the frequency or severity of menopause-related hot flashes.

Design, setting, and participants

This randomized, double-blinded, placebo-controlled clinical trial included perimenopausal or postmenopausal women reporting 7 o

SUBMITTER: Huang AJ 

PROVIDER: S-EPMC10242506 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature