HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive ART.

ABSTRACT:

Objective

Despite long-term suppressive cART, the activation level of T lymphocytes remains significantly high HIV-infected individuals. This study aims to unravel the relationship between CD8+ T cell activation and HIV DNA reservoir.

Design/methods

In this retrospective study, 82 HIV-infected patients receiving suppressive cART for ≥8 years were included. Total HIV-1 DNA and expression of CD38 and HLA-DR in CD8+ T cell were quantified repeatedly during long-term follow-up. Longitudinal correlation between HIV-1 DNA and CD8+ T cell activation level was analysed using generalized estimating equation (GEE) model.

Results

Significant decrease of both total HIV-1 DNA and CD8+ T cell activation level were observed after combined antiretroviral therapy (cART) initiation. Ho

SUBMITTER: Zhu T 

PROVIDER: S-EPMC10242515 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature