Linear epitopes on the capsid protein of norovirus commonly elicit high antibody response among past-infected individuals.

ABSTRACT:

Background

Human norovirus (HuNoV) is the leading cause of acute nonbacterial gastroenteritis globally, and its infection is usually self-limited, so most people become past Norovirus (NoV)-infected individuals. It is known that some antibody responses may play a critical role in preventing viral infection and alleviating disease; however, the characteristics and functions of particular antibody responses in persons with previous infections are not fully understood. Capsid proteins, including VP1 and VP2, are crucial antigenic components of NoV and may regulate antibody immune responses, while epitope-specific antibody responses to capsid proteins have not been comprehensively characterized.

Methods

We prepared purified VP1 and VP2 proteins by ion exchange chromatography and

SUBMITTER: Deng Y 

PROVIDER: S-EPMC10242594 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature