Risk prediction model construction for post myocardial infarction heart failure by blood immune B cells.

ABSTRACT:

Background

Myocardial infarction (MI) is a common cardiac condition with a high incidence of morbidity and mortality. Despite extensive medical treatment for MI, the development and outcomes of post-MI heart failure (HF) continue to be major factors contributing to poor post-MI prognosis. Currently, there are few predictors of post-MI heart failure.

Methods

In this study, we re-examined single-cell RNA sequencing and bulk RNA sequencing datasets derived from the peripheral blood samples of patients with myocardial infarction, including patients who developed heart failure and those who did not develop heart failure after myocardial infarction. Using marker genes of the relevant cell subtypes, a signature was generated and validated using relevant bulk datasets and human bloo

SUBMITTER: Sun H 

PROVIDER: S-EPMC10242647 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature