Identification of m6A-related lncRNAs as prognostic signature within colon tumor immune microenvironment.

ABSTRACT:

Background

The current study probed prognosis-related potential for m6A-related lncRNAs signatures within colon tumor immune microenvironment (TIM).

Methods

After downloading transcriptomic datasets for colon cancer (CC) patients from The Cancer Genome Atlas (TCGA), they were divided, in a 1:1 ratio, within training or test datasets. m6A-related lncRNAs were then scrutinized across such dataset using Pearson correlation assessment before generating a m6A-related lncRNAs prognosis-related model using the training dataset. The latter was then validated with the test and the whole dataset. In addition, we compared the differences of TIM and the estimated IC50 of drug response between the high- and low-risk groups.

Results

Overall survival (OS) resulted as linked with 11

SUBMITTER: Cao L 

PROVIDER: S-EPMC10242659 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature