Synthesis and crystal structure studies of 5-(tri-fluoro-meth-yl)-1,3,4-thia-diazol-2(3H)-one at 180 K.

ABSTRACT: The synthesis and crystal structure of C₃HF₃N₂OS, systematic name 5-(tri-fluoro-meth-yl)-1,3,4-thia-diazol-2(3H)-one (5-TMD-2-one), a compound containing the pharmacologically important heterocycle 1,3,4-thia-diazole, is presented. The asymmetric unit comprises six independent mol-ecules (Z' = 6), all of which are planar. The r.m.s. deviations from each mean plane range from 0.0063 to 0.0381 Å, not including the CF₃ fluorine atoms. Within the crystal, two of the mol-ecules form hydrogen-bonded dimers that in turn combine with inversion-related copies to form tetra-meric constructs. Similar tetra-mers, but lacking inversion symmetry, are formed by the remaining four mol-ecules. The tetra-mers are linked into tape-like motifs by S⋯O and O⋯O close contacts. The environments of each symmetry-independent mol-ecule were compared via a Hirshfeld surface analysis. The most abundant atom-atom contacts are between fluorine atoms, while the strongest result from N-H⋯O hydrogen bonds.

SUBMITTER: Geetha D 

PROVIDER: S-EPMC10242744 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature